Manipulating genetic architecture to reveal fitness relationships

A Genetic-DEA Approach to Reveal Property Rights Priorities

Pipelined Genetic Architecture with Fitness on the Fly

One of the main bottlenecks in Genetics Algorithms is the fitness evaluation for each individual. In this work, we propose a new fitness evaluation method, which will solve the bottleneck calculating a fitness on the j y .

Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness

The concept of robustness in biology has gained much attention recently, but a mechanistic understanding of how genetic networks regulate phenotypic variation has remained elusive. One approach to understand the genetic architecture of variability has been to analyze dispensable gene deletions in model organisms; however, the most important genes cannot be deleted. Here, we have utilized two sy...

Inclusive fitness in human relationships

For Homo sapiens, inclusive fitness theory goes well beyond ‘kin’. As William Hamilton hypothesized, genes can increase the probability of their own survival by bringing about the reproduction of not only family members with whom they share copies, but also of any individuals with whom they share copies. Research with Hamilton’s theory on people is less well known and remains controversial. Thi...

Fitness Uniform Selection to Preserve Genetic Diversity

In evolutionary algorithms, the fitness of a population increases with time by mutating and recombining individuals and by a biased selection of more fit individuals. The right selection pressure is critical in ensuring sufficient optimization progress on the one hand and in preserving genetic diversity to be able to escape from local optima on the other. We propose a new selection scheme, whic...